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One advantage of playing at the two, Wiggins said, was that he likely would see smaller defenders playing him.
Four starters scored in double figures as U led throughout.
The team also got a combined 48 points from Karl-Anthony Towns and Andrew Wiggins.
He helped the U.S. hockey team earn a silver medal at the 1972 Winter Olympics.
Karl-Anthony Towns had 25 points and 16 rebounds, Andrew Wiggins scored 23 and the Minnesota Timberwolves improved to 2-0 since trading Jimmy Butler with a 107-100 victory over the New Orleans Pelicans on Wednesday night.